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Alimta dan Fenortho

Penentuan interaksi Alimta dan Fenortho dan kemungkinan pengambilan ubat-ubat itu secara bersama-sama.

Hasil pemeriksaan:

Alimta <> Fenortho

Relevan: 24.06.2022 Pengulas: MD P.M. Shkutko, in

Dalam pangkalan rujukan rasmi yang digunakan untuk membuat perkhidmatan ini, telah didapati interaksi yang dicatat secara statistik berasaskan oleh hasil penyelidikan, yang boleh membawa pada akibat negatif untuk kesihatan pesakit, atau pun meningkatkan kesan positif timbal balik. Dikehendaki rundingan doktor untuk menyelesaikan perkara pengambilan ubat-ubatan secara bersama-sama.

Pengguna:

Menggunakan PEMEtrexed bersama-sama dengan fenoprofen boleh meningkatkan kesan PEMEtrexed. Hubungi doktor anda jika anda mengalami demam, menggigil, sakit badan, gejala flu, mulut luka atau putih patch, dan parah diare. PEMEtrexed lebih sel-sel darah yang membantu tubuh anda melawan jangkitan. Ini bisa membuatnya lebih mudah bagi anda untuk berdarah dari cedera atau sakit dari berada di sekitar orang lain yang sakit. Untuk pastikan sel-sel darah anda tidak mendapatkan terlalu rendah, darah anda akan perlu untuk diuji secara teratur. Jika doktor anda tidak menetapkan ubat-ubatan ini bersama-sama, anda mungkin perlukan pelarasan dos atau ujian khas untuk selamat menggunakan kedua-dua ubat-ubatan. Ia adalah penting untuk memberitahu anda dokter tentang semua yang lain ubat-ubatan anda menggunakan, termasuk vitamin dan herba. Jangan berhenti menggunakan mana-mana ubat-ubatan tanpa berbicara dengan anda, doktor.

Profesional:

MENYESUAIKAN DOS SELANG: Coadministration dengan ubat bukan steroid anti-inflamasi (Nsaid) boleh meningkatkan plasma kepekatan pemetrexed. Mekanisme tidak pernah digambarkan tapi mungkin berkaitan dengan NSAID menghalang buah pinggang prostaglandin. Gunakan Nsaid telah dikaitkan dengan nefropati dikategorikan sebagai ketinggian di serum peluang untuk bertemu muka dan BUN, tiub kebekuan, glomerulitis, ginjal papillary kebekuan, akut celahan radang buah pinggang, nefrotik sindrom, dan gagal ginjal. Sejak pemetrexed terutamanya dihapuskan tidak berubah dengan ginjal penyingkiran, coadministration dengan Nsaid boleh mengakibatkan ditangguhkan dan/atau menurun pelepasan. Setiap hari ibuprofen dos 400 mg empat kali sehari telah ditunjukkan untuk mengurangkan pemetrexed pelepasan sebanyak 20% pada pasien dengan biasa fungsi ginjal, sedangkan aspirin di 325 mg setiap 6 jam tidak. Kesan yang lebih tinggi dos ibuprofen atau aspirin adalah tidak diketahui.

PENGURUSAN: Ibuprofen pada 400 mg dan aspirin di 325 mg empat kali sehari, atau kurang, boleh digunakan dengan pemetrexed pada pasien dengan biasa fungsi ginjal. Bagaimanapun, awas dinasihatkan pada pasien dengan ringan untuk sederhana kekurangan buah pinggang (peluang untuk bertemu muka pelepasan 45 79 mL/min). Pesakit ini harus elakkan mengambil Nsaid dengan singkat penghapusan setengah kehidupan (contohnya, diclofenac, etodolac, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic asid, sulindac, tolmetin, dos yang rendah salisilat) 2 hari sebelum 2 hari setelah pemetrexed pentadbiran. Jika seiring pentadbiran adalah perlu, pesakit perlu dipantau dengan teliti untuk keracunan, terutama myelosuppression, nephrotoxicity, dan pencernaan keracunan. Tanpa data mengenai gunakan dengan Nsaid dengan lagi separuh hidup, pegangan NSAID dos untuk setidaknya 5 hari sebelum 2 hari setelah pemetrexed pentadbiran disarankan.

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