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Acetaminophen and pyrilamine dan Dilantin Infatabs

Penentuan interaksi Acetaminophen and pyrilamine dan Dilantin Infatabs dan kemungkinan pengambilan ubat-ubat itu secara bersama-sama.

Hasil pemeriksaan:

Acetaminophen and pyrilamine <> Dilantin Infatabs

Relevan: 20.04.2023 Pengulas: MD P.M. Shkutko, in

Dalam pangkalan rujukan rasmi yang digunakan untuk membuat perkhidmatan ini, telah didapati interaksi yang dicatat secara statistik berasaskan oleh hasil penyelidikan, yang boleh membawa pada akibat negatif untuk kesihatan pesakit, atau pun meningkatkan kesan positif timbal balik. Dikehendaki rundingan doktor untuk menyelesaikan perkara pengambilan ubat-ubatan secara bersama-sama.

Pengguna:

Menggunakan paracetamol bersama-sama dengan phenytoin mungkin mengubah kesan paracetamol dan menyebabkan efek samping yang serius yang mungkin mempengaruhi hati anda. Panggilan anda doktor segera jika anda mengalami demam, menggigil, bersama sakit atau bengkak, yang berlebihan keletihan atau kelemahan, pendarahan yang luar biasa atau lebam, kulit ruam atau gatal-gatal, kehilangan selera, mual, muntah, atau kuning kulit atau putih matamu. Jika doktor anda tidak menetapkan ubat-ubatan ini bersama-sama, anda mungkin perlukan pelarasan dos atau ujian khas untuk selamat mengambil kedua-dua ubat-ubatan. Ia adalah penting untuk memberitahu anda dokter tentang semua yang lain ubat-ubatan anda menggunakan, termasuk vitamin dan herba. Jangan berhenti menggunakan mana-mana ubat-ubatan tanpa berbicara dengan anda, doktor.

Profesional:

MONITOR: Hydantoins mungkin peningkatan potensi hepatoksisiti paracetamol dan penurunan itu farmakologis kesan. Mekanisme mungkin berkaitan dengan induksi paracetamol metabolisme dengan peningkatan akibat hepatotoxic metabolik. Interaksi ini adalah kebimbangan terbesar dalam kes-kes paracetamol berlebihan.

PENGURUSAN: Pemantauan fungsi hati disarankan. Pesakit harus agar dos yang besar atau penggunaan yang berpanjangan paracetamol.

Sumber

Miners JO, Attwood J, Birkett DJ "Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways." Clin Pharmacol Ther 35 (1984): 480-6
Brackett CC, Bloch JD "Phenytoin as a possible cause of acetaminophen hepatotoxicity: Case report and review of the literature." Pharmacotherapy 20 (2000): 229-33
Bivins BA, Rapp RP, Griffen WO Jr, Blouin R, Bustrack J "Dopamine-phenytoin interaction. A cause of hypotension in the critically ill." Arch Surg 113 (1978): 245-9
Lorenzi M, Karam JH, Tsalikian E, Bohannon NV, Gerich JE, Forsham PH "Dopamine during alpha- or beta-adrenergic blockade in man. Hormonal, metabolic, and cardiovascular effects." J Clin Invest 63 (1979): 310-7
Minton NA, Henry JA, Frankel RJ "Fatal paracetamol poisoning in an epileptic." Hum Toxicol 7 (1988): 33-4
Prescott LF, Critchley JA "Drug interactions affecting analgesic toxicity." Am J Med 75 (1983): 113-6

Acetaminophen and pyrilamine

Nama jenerik: acetaminophen / pyrilamine

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Sinonim: tidak

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