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Nefazodone Hydrochloride dan Tacrolimus Granules for Suspension

Penentuan interaksi Nefazodone Hydrochloride dan Tacrolimus Granules for Suspension dan kemungkinan pengambilan ubat-ubat itu secara bersama-sama.

Hasil pemeriksaan:

Nefazodone Hydrochloride <> Tacrolimus Granules for Suspension

Relevan: 01.09.2022 Pengulas: MD P.M. Shkutko, in

Dalam pangkalan rujukan rasmi yang digunakan untuk membuat perkhidmatan ini, telah didapati interaksi yang dicatat secara statistik berasaskan oleh hasil penyelidikan, yang boleh membawa pada akibat negatif untuk kesihatan pesakit, atau pun meningkatkan kesan positif timbal balik. Dikehendaki rundingan doktor untuk menyelesaikan perkara pengambilan ubat-ubatan secara bersama-sama.

Pengguna:

Menggunakan tacrolimus bersama-sama dengan nefazodone boleh meningkatkan kesan tacrolimus dan menyebabkan kerosakan pada buah pinggang atau menyebabkan saraf kehilangan. Beritahu doktor anda jika anda mengalami pusing, kebas, kulit kesemutan, bergerak-gerak otot, atau kejang-kejang yang boleh tanda-tanda kerusakan saraf. Berbicara dengan anda doktor jika anda mengalami demam, menggigil, sakit badan, gejala flu, dan sakit yang teruk di perut atas menyebarkan untuk anda kembali. Jika anda mengambil kedua-dua ubat-ubatan bersama-sama, beritahu doktor anda jika anda mempunyai gejala-gejala ini. Kau mungkin perlukan pelarasan dos atau khas ujian jika anda menggunakan kedua-dua ubat-ubatan. Ia adalah penting untuk memberitahu anda dokter tentang semua yang lain ubat-ubatan anda menggunakan, termasuk vitamin dan herba. Jangan berhenti menggunakan mana-mana ubat-ubatan tanpa berbicara dengan anda, doktor.

Profesional:

MEMANTAU: Coadministration dengan kuat inhibitor CYP450 3A4 mungkin meningkatkan kepekatan darah tacrolimus, yang terutamanya kekal oleh isoenzyme dalam kedua-dua usus dan hati. Ada banyak laporan dan farmakokinetik di perubatan kesusasteraan tacrolimus interaksi dengan pelbagai kuat CYP450 3A4 inhibitor, termasuk azole anti agen, macrolide antibiotik, dan protease inhibitor. Nephrotoxicity dan lain-lain kesan buruk (contohnya, hyperkalemia, hiperglisemia, hemolitik, hemolitik uremic sindrom, keracunan saraf) dalam persatuan dengan ketara tinggi tacrolimus tahap darah telah dilaporkan, memerlukan besar pengurangan atau gangguan di tacrolimus dos.

PENGURUSAN: Awas dinasihatkan apabila tacrolimus digunakan dengan kuat CYP450 3A4 inhibitor. Dos pengurangan dan/atau perpanjangan dos selang untuk tacrolimus mungkin akan diperlukan. Kerap pemantauan tacrolimus seluruh darah tahap yang harus dilakukan semasa dan selepas pemberhentian CYP450 3A4 penindas, dan tacrolimus dos diselaraskan oleh itu. Di samping itu, pesakit perlu dipantau dengan teliti untuk pembangunan kesan buruk yang serius seperti nephrotoxicity, limfoma dan lain-lain keganasan, jangkitan, diabetes, keracunan saraf (gegaran, paraesthesia, encephalopathy, delirium, koma), hyperkalemia, BAGI perpanjangan, hipertropi jantung, dan tekanan darah tinggi. Pesakit harus disarankan untuk segera mencari perhatian perubatan jika mereka mengalami gejala-gejala yang bisa menunjukkan kejadian torsade de pointes seperti pening, kepala, pengsan, denyutan, jantung tidak teratur irama, sesak nafas, atau pengsan.

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